Metabolomics - what nomenclature to use?

Tamas Komives


This Opinion paper was written to initiate a discussion on the nomenclature used in metabolomic studies. The paper is based on the belief that the currently used classification of metabolites as "primary" and "secondary" are inaccurate and somewhat misleading. Of the alternative names previously suggested in the literature we strongly support the use of the names "general" and "specific metabolites".

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Bennett, J.W., Bentley, R., 1989. What’s in a Name? Microbial Secondary Metabolism, in: Advances in Applied Microbiology. Elsevier, pp. 1–28.

Chae, L., Kim, T., Nilo-Poyanco, R., Rhee, S.Y., 2014. Genomic signatures of specialized metabolism in plants. Science 344, 510–513.

Firn, R.D., Jones, C.G., 2009. A Darwinian view of metabolism: molecular properties determine fitness. J. Exp. Bot. 60, 719–726.

Foster, J.W., 1949. Chemical Activities of Fungi. Acade-mic Press, New York.

Frank, J.M., 1998. Special metabolites in relation to conditions of growth, in:

Frisvad, J., Arora, D., Bridge, P. (Eds.), Chemical Fungal Taxonomy. Marcel Dekker, pp. 321–344.

Gaden, E.L., 1959. Fermentation process kinetics. J. Biochem. Microbiol. Technol. Eng. 1, 413–429.

Haard, N.F., 1983. Stress Metabolites, in: Lieberman, M. (Ed.), Post-Harvest Physiology and Crop Preser-vation. Springer US, Boston, MA, pp. 299–314.

Harborne, J.B.,1973. Phytochemical methods: a guide to modern techniques of plant analysis. London, Chap-man & Hall

Hartmann, T., 2007. From waste products to ecochemi-cals: Fifty years research of plant secondary metabo-lism. Phytochemistry 68, 2831–2846.

Komives, T., Casida, J.E., 1983. Acifluorfen increases the leaf content of phytoalexins and stress meta-bolites in several crops. J. Agric. Food Chem. 31, 751–755.

Kossel, A., 1891. Uber diechemische Zusammensetzung der Zelle. Bois-Reymond’s Arch. Arch Anat Physiol Physiol Abt 8, 181–186.

Spinoza, B. de, 2001. Ethics (translated by W.H. White and A.K. Stirling). Wordsworth Editions.

Szekacs, A., Komives., T., 2017. Research directions in plant protection chemistry. Ecocycles 3 (2): 4-12.

Walker, J.B., 1974. Biosynthesis of the monoguanidina-ted inositol moiety of bluensomycin, a possible evo-lutionary precursor of streptomycin. J. Biol. Chem. 249, 2397–2404.

Zhang, L., Demain, A.L. (Eds.), 2005. Natural Products. Humana Press, Totowa, NJ.



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ISSN 2416-2140
DOI prefix 10.19040